Concept paper on no need for revision of the guideline on medicinal products for the treatment of Alzheimer's disease and other dementias

Analysis of the incidence and mortality rate of Alzheimer's and other dementias during the last 30 years in Iran

Introduction: Assessing the course of Alzheimer's disease and other dementias is very important due to lack of a definitive treatment, increase in life expectancy, and aging population. This study aimed to investigate the long-term trend in the incidence and mortality rate of Alzheimer's and other dementias in Iran during 1990-2019. Materials and Methods: Age-Standardized Incidence Rate (ASIR) ...

COMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE (CHMP) DRAFT GUIDELINE ON MEDICINAL PRODUCTS FOR THE TREATMENT OF ALZHEIMER’S DISEASE AND OTHER DEMENTIAS DRAFT AGREED BY THE EFFICACY WORKING PARTY April – June 2007 ADOPTION BY CHMP FOR RELEASE FOR CONSULTATION

Appendix 4 to the guideline on the evaluation of anticancer medicinal products in man

Revision 1 of this appendix refers to the addition of point 6 – ‘The role of the pathological Complete Response as an endpoint in neoadjuvant breast cancer studies’ (EMA/CHMP/151853/2014). All other content remains unchanged. For background information please see ‘Concept paper on the need to revise Condition – Specific guidance, Appendix 4 to the guideline on the evaluation of anticancer medic...

Concept paper on the revision of the guideline on similar biological medicinal products containing biotechnology-derived proteins as active substance: non-clinical and clinical issues

Concept paper on the revision of the guideline on similar biological medicinal products containing biotechnology-derived proteins as active substance: non-clinical and clinical issues

P 97: Neurodegeneration Induced by Tau protein

Tau is one of several types of microtubule-associated proteins (MAPs), responsible for the assembly and stability of microtubule networks that is present only in neurons and predominantly localized in axons which its functions are tightly regulated by phosphorylation. Via as yet unknown mechanisms, tau becomes hyperphosphorylated and accompanies with neuronal degeneration, loss of synapses...